Mac Cheese Meatloaf Casserole blends two comfort food classics into one irresistible dish. Imagine a savory meatloaf base topped with creamy, cheesy macaroni that warms the heart and fills the belly. This dish is perfect for family dinners, holiday gatherings, or any occasion where comfort food is required. Let’s dive into the details of making this delightful casserole that is sure to become a staple in your recipe book!
Why You’ll Love This Mac Cheese Meatloaf Casserole
This Mac Cheese Meatloaf Casserole is a culinary gem that combines the best of two worlds: hearty meatloaf and creamy macaroni and cheese. Here are a few reasons to love it:
- It’s a crowd-pleaser that kids and adults alike will enjoy.
- Combines multiple food groups in one dish, making it a wholesome meal.
- Easy to prepare and can be made ahead of time.
- Perfect for leftovers, as the flavors deepen the next day.
- It’s customizable; you can add veggies or switch up the cheese.
- Great for meal prep, especially for busy weeknights.
With its comforting profile, this dish is an American classic that fits perfectly into any comfort food meatloaf casserole category.
Ingredients for Mac Cheese Meatloaf Casserole
Gather these items:
- 1 ½ pounds ground beef (or turkey/chicken)
- 1 large egg
- 1 cup breadcrumbs (use gluten-free for a gluten-free option)
- 1 tablespoon Worcestershire sauce
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1 teaspoon dried basil
- Salt and pepper to taste
- 2 cups elbow macaroni (or pasta of choice)
- 2 cups shredded cheddar cheese (or mix of cheddar and mozzarella)
- 1 ½ cups milk
- 2 tablespoons unsalted butter
- 1 tablespoon all-purpose flour
- 1 teaspoon Dijon mustard (optional)
- 1 cup shredded mozzarella cheese
- Fresh parsley (optional for garnish)
How to Make Mac Cheese Meatloaf Casserole Step-by-Step
- Step 1: Preheat oven to 375°F (190°C). Grease a 9×13-inch casserole dish.
- Step 2: In a large bowl, combine ground beef, egg, breadcrumbs, Worcestershire sauce, garlic powder, onion powder, basil, salt, and pepper. Mix until combined. Form into a loaf and place in the casserole dish. Bake for 30 minutes.
- Step 3: While the meatloaf bakes, cook macaroni according to package instructions. Drain and set aside.
- Step 4: In a saucepan, melt butter. Whisk in flour and cook for 1-2 minutes. Gradually add milk, whisking continuously, and cook until the sauce thickens. Stir in cheese and Dijon mustard (if using). Season with salt and pepper.
- Step 5: After baking the meatloaf, layer the cooked macaroni on top. Pour cheese sauce over the pasta. Sprinkle mozzarella cheese on top and bake for another 10-15 minutes, or until bubbly and golden brown.
- Step 6: Let the casserole rest for 10 minutes before serving. Garnish with parsley.

Pro Tips for the Perfect Mac Cheese Meatloaf Casserole
Keep these in mind:
- Use lean ground meat for a healthier option.
- Feel free to add vegetables like peas or broccoli for extra nutrition.
- For a spicy kick, add some diced jalapeños to the meat mixture.
Best Ways to Serve Mac Cheese Meatloaf Casserole
This delicious dish can be served in various ways:
- Pair it with a simple green salad for a complete meal.
- Serve with garlic bread for an extra indulgent experience.
- Top with extra cheese before the final bake for more cheesiness.
How to Store and Reheat Mac Cheese Meatloaf Casserole
After cooking, let the casserole cool completely before storing it. To store, place it in an airtight container and refrigerate for up to 3 days. For reheating, simply warm it in the oven at 350°F (175°C) until heated through. This dish is perfect for meal prep, making it a go-to for a quick, hearty dinner.
Frequently Asked Questions About Mac Cheese Meatloaf Casserole
What’s the secret to perfect Mac Cheese Meatloaf Casserole?
The key to making the perfect meatloaf macaroni casserole dish lies in balancing the flavors of the meatloaf with the creaminess of the cheese sauce. Ensure your meatloaf is well-seasoned and don’t skimp on cheese!
Can I make Mac Cheese Meatloaf Casserole ahead of time?
Yes, you can prepare this comforting mac cheese and meatloaf bake ahead of time. Assemble the casserole but do not bake it. Cover and refrigerate for up to 24 hours before baking.
How do I avoid common mistakes with Mac Cheese Meatloaf Casserole?
To avoid mistakes, make sure the meatloaf is fully cooked before adding the macaroni and cheese. Also, ensure the cheese sauce is thick enough to coat the pasta without being too runny.
Variations of Mac Cheese Meatloaf Casserole You Can Try
Feel free to experiment with your macaroni meatloaf bake recipe. Here are a few variations:
- Substitute ground turkey or chicken for a lighter option.
- Incorporate different cheeses like Monterey Jack or a spicy pepper jack.
- Add cooked vegetables like spinach or bell peppers into the mixture for added nutrition.
- For a gluten-free option, use gluten-free breadcrumbs and pasta.

For more delicious recipes, check out our Cheesy Baked Fajita Chicken or Meat Potato Casserole Recipe. If you’re looking for a sweet treat, try our Apple Bundt Cake Recipe!
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Irresistible Mac Cheese Meatloaf Casserole Recipe
- Total Time: 1 hour 10 minutes
- Yield: 6 servings 1x
- Diet: Gluten Free
Description
Mac and Cheese Meatloaf Casserole blends two comfort food classics into one irresistible dish. A savory meatloaf base is topped with creamy mac and cheese, making it the perfect family dinner for any occasion.
Ingredients
- 1 ½ pounds ground beef (or turkey/chicken)
- 1 large egg
- 1 cup breadcrumbs (use gluten-free for a gluten-free option)
- 1 tablespoon Worcestershire sauce
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1 teaspoon dried basil
- Salt and pepper to taste
- 2 cups elbow macaroni (or pasta of choice)
- 2 cups shredded cheddar cheese (or mix of cheddar and mozzarella)
- 1 ½ cups milk
- 2 tablespoons unsalted butter
- 1 tablespoon all-purpose flour
- 1 teaspoon Dijon mustard (optional)
- Salt and pepper to taste
- 1 cup shredded mozzarella cheese
- Fresh parsley (optional for garnish)
Instructions
- Preheat oven to 375°F (190°C). Grease a 9×13-inch casserole dish.
- In a large bowl, combine ground beef, egg, breadcrumbs, Worcestershire sauce, garlic powder, onion powder, basil, salt, and pepper. Mix until combined. Form into a loaf and place in the casserole dish. Bake for 30 minutes.
- While the meatloaf bakes, cook macaroni according to package instructions. Drain and set aside.
- In a saucepan, melt butter. Whisk in flour and cook for 1-2 minutes. Gradually add milk, whisking continuously, and cook until the sauce thickens. Stir in cheese and Dijon mustard (if using). Season with salt and pepper.
- After baking the meatloaf, layer the cooked macaroni on top. Pour cheese sauce over the pasta. Sprinkle mozzarella cheese on top and bake for another 10-15 minutes, or until bubbly and golden brown.
- Let the casserole rest for 10 minutes before serving. Garnish with parsley.
Notes
- Use lean ground meat for a healthier option.
- Feel free to add vegetables like peas or broccoli for extra nutrition.
- Prep Time: 20 minutes
- Cook Time: 50 minutes
- Category: Main Dish
- Method: Baking
- Cuisine: American
Nutrition
- Serving Size: 1 serving
- Calories: 400
- Sugar: 3g
- Sodium: 800mg
- Fat: 25g
- Saturated Fat: 12g
- Unsaturated Fat: 8g
- Trans Fat: 0g
- Carbohydrates: 35g
- Fiber: 2g
- Protein: 20g
- Cholesterol: 80mg
